Learn why recovery is possible with RYONCIL
See results from a study of children with steroid-refractory acute GvHD. See what happened when they got RYONCIL after steroids did not work.
Results with RYONCIL
RYONCIL may provide the help you’ve been hoping for
In the past, children with steroid-refractory acute GvHD had very few treatment choices. RYONCIL is changing that, giving hope to families living with steroid-refractory acute GvHD.
RYONCIL is the first and only FDA-approved steroid-refractory acute GvHD treatment for children 2 months of age and older. It is the only approved option for patients under 12 years of age.
Learn why RYONCIL is differentRYONCIL is the only MSC therapy approved by the FDA
RYONCIL is different from other medicines used to treat adults with steroid-refractory acute GvHD. It’s a first-of-its kind treatment approved just for children.
RYONCIL is made from living cells. This is called cell therapy. These cells are called mesenchymal stromal cells (or MSCs). They come from the bone marrow of healthy adult donors in the United States. They have been carefully tested for safety.
Unlike some treatments, RYONCIL does not require donor matching. It’s ready to use when your child needs it. This makes it a convenient option for many families.
RYONCIL is the first and only FDA-approved MSC treatment available in the United States.
RYONCIL works differently than a steroid
RYONCIL works in a different way than a steroid. It’s a special type of cell therapy that may calm the immune system instead of weakening it. This gives your child’s body a chance to recover from steroid-refractory acute GvHD.
After transplant
Donor stem cells (the “graft”) may send signals to attack healthy cells in the patient, causing the immune system to go into overdrive, resulting in acute GvHD.
Inflammation goes up
Attack signals may cause inflammation that affects the gastrointestinal (GI) tract, liver, and/or skin.
Treatment begins
After acute GvHD is diagnosed, doctors may treat with steroids and other medicines. In about half of children, steroids don’t work well enough.
RYONCIL treatment
When steroids fail to control acute GvHD, RYONCIL can be used to send special cells into the bloodstream to help calm the immune system.
Inflammation goes down
Inflammation may go down, reducing the number of overactive immune cells.
Calm immune response
By calming the inflammation signals, RYONCIL may help bring the immune system back into balance.
RYONCIL is the only steroid-refractory acute GvHD medicine of its kind. It may provide the help you’ve been hoping for.
Watch Dr Carpenter discuss treatment with RYONCIL
“When you inject the cells…they modulate the immune system in a way to decrease the inflammation"— Dr Paul Carpenter, acute GvHD expert
Get support at every step
Learning that your child has steroid-refractory acute GvHD can feel scary. But it’s important to know that you are not alone. Support is available to help your family move forward.
Explore support resources