For families facing steroid-refractory acute GvHD, knowing what comes next can help. RYONCIL is a proven therapy with a clear treatment schedule.
Learn more about RYONCIL treatment schedule
Learn how your experience with RYONCIL could make a meaningful difference for other patients and families affected by steroid-refractory acute GvHD.
Share your storyWhere your child gets RYONCIL depends on their specific needs. It may take place at a transplant center, a hospital, or an outpatient clinic. Your care team will help you choose what is right for your family.
RYONCIL is a special medicine made from living cells. This is also known as cell therapy. It's given through an IV. This usually happens twice a week for 4 weeks. That's 8 infusions, total. It's not a pill. No donor matching is needed.
The care team will prescribe the dose of RYONCIL that's right for your child. This will be guided by his or her weight. Each infusion will be spaced at least 3 days apart. This gives your child's body the chance to benefit from treatment.
Your care team can help create a treatment plan for a weekly routine that works with your family's schedule.
Know what to expect before, during, and after treament
Talk with your child’s care team about what to expect with RYONCIL.
“It's given IV, so we don't have to worry about…being able to take medicines, which is a challenge for a lot of our young patients.”— Dr Andrew Harris, acute GvHD expert
Your child will be watched during treatment. About 30 minutes to an hour before each infusion, your child will get medicines to help lower the chance of an allergic reaction. After each infusion, the care team will check for fever, chills, or other reactions. Then your child can go back to his or her regular routine.
After about 28 days, the care team will decide if more doses are needed.
If all signs of steroid-refractory acute GvHD have gone away: no more infusions are needed.
If steroid-refractory acute GvHD comes back after fully going away: the full RYONCIL routine may be repeated. That would be 2 infusions per week for 4 more weeks.
If some signs got better while others stayed the same: 1 more infusion per week may be given for another 4 weeks. This would be 4 more infusions.
If there is no response, talk with your child’s healthcare team about other options.
See why RYONCIL is different
Learn more about the first and only FDA-approved steroid-refractory acute GvHD treatment for children 2 months of age and older.
About RYONCIL
Get support at every step
Learning that your child has steroid-refractory acute GvHD can feel scary. But it’s important to know that you are not alone. Support is available to help your family move forward.
Get support resources
Have questions? We have answers
Get answers to common questions about steroid-refractory acute GvHD and treatment with RYONCIL.
Explore Q&A
RYONCIL is a prescription medicine used to treat a condition called steroid-refractory acute graft versus host disease (SR-aGvHD) in children 2 months and older.
Do not receive Ryoncil if you are allergic to DMSO or porcine and bovine proteins (e.g., pigs or cows).
Ryoncil is not recommended if you are pregnant. Talk to your doctor about the risks and benefits of breastfeeding during Ryoncil treatment.
The most common side effects include infections, fever, bleeding, swelling, stomach pain, high blood pressure, vomiting, irregular heartbeat, diarrhea, rash, joint pain, low blood pressure, cough, and trouble breathing.
Tell your doctor about all your medical conditions, allergies, and if you are pregnant or breastfeeding.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800-FDA-1088.
For additional information, see full Prescribing Information.
RYONCIL is a prescription medicine used to treat a condition called steroid-refractory acute graft versus host disease (SR-aGvHD) in children 2 months and older.
Do not receive Ryoncil if you are allergic to DMSO or porcine and bovine proteins (e.g., pigs or cows).
Ryoncil is not recommended if you are pregnant. Talk to your doctor about the risks and benefits of breastfeeding during Ryoncil treatment.
The most common side effects include infections, fever, bleeding, swelling, stomach pain, high blood pressure, vomiting, irregular heartbeat, diarrhea, rash, joint pain, low blood pressure, cough, and trouble breathing.
Tell your doctor about all your medical conditions, allergies, and if you are pregnant or breastfeeding.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800-FDA-1088.
For additional information, see full Prescribing Information.
